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KMID : 0861020120270030095
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Korea Journal of Herbology
2012 Volume.27 No. 3 p.95 ~ p.100
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A Study on the Acute Toxicity of Leejung-tang(Lizhong-tang) and Fermented Leejung-tang(Lizhong-tang) Extract in ICR Mice
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Jung Young-Pil
Hwang Yun-Hwan
Lee Ji-Hye
Yim Nam-Hui
Cho Won-Kyung
Ma Jin-Yeul
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Abstract
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Objectives: This study was carried out to investigate the acute toxicity and safety of Leejung-tang(Lizhong-tang)
and fermented Leejung-tang(Lizhong-tang) extract.
Methods: To evaluate their acute toxicity and safety, 0(control group), 1250, 2500 and 5000 ㎎/㎏ of
Leejung-tang(Lizhong-tang) and fermented Leejung-tang (Lizhong-tang) extracts were orally administered to
35 male and 35 female ICR mice. After a single administration, we observed survival rates, general toxicity,
changes of body weight, and autopsy.
Results: Compared with the control group, we could not find any toxic alteration in any of treated groups
(1250, 2500 and 5000 ㎎/㎏).
Conclusions: LD50 of Leejung-tang(Lizhong-tang) and fermented Leejung-tang (Lizhong-tang) were over 5000
㎎/㎏ and it is very safe to ICR mice.
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KEYWORD
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Leejung-tang, Lizhong-tang, acute toxicity, Fermentation, Safety, LD50
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